linear regression formula multi local regression the kernel-weighted local polynomial regression (kwlpr) approach

 https://jcheminf.biomedcentral.com/articles/10.1186/s13321-021-00484-5

 https://en.wikipedia.org/wiki/Polynomial_regression

https://en.wikipedia.org/wiki/Local_regression 

https://www.i2tutorials.com/difference-between-simple-linear-regression-and-multi-linear-regression-and-polynomial-regression/